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Document Type

Original Study

Abstract

Objective : The present study was designated to evaluate the effect oflepidiumsativum extract on structure and density of bone in immunosuppressedrats with induced chronic periodontitis histologically, hostometricallyas well as radiodensitometric analysis by digital radiography assessment(vista scan). Materials and methods: A total 36 wistar male ratswere divided randomly into 6 groups (6 rats/group). The study samplewas divided into:I - Control group: in this group rats were fed witha normal diet.II-Control group with ligature: without receiving dexamethasoneinjection, a sub marginal cotton ligature.III-Vehicle group:in this group rats were received a weekly dose of dexamethasone for 6weeks and received sub marginal cotton ligature (no treatment). SRP1 (methanol group): rats were received methanol extract for 30 days,these were subjected to scaling and root planning (SRP). SRP 2 (waterygroup): in this group rats were subjected to (SRP). SRP 3 group submittedonly to SRP and received no further treatment.Results: methanolextract has better anabolic effect on bone and regenerative on periodontalligaments than watery extract.This could be explained by the factthat lepidiumsativum possesses anti-inflammatory, immunomodulatoryproperties and antioxidative activity that may resolve periodontal inflammation.

Keywords

immunosuppression; dexamethasone; Chronic Periodontitis; lepidiumsativum; Extract; SRP

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