Effect of Polycaprolactone Nanofiber Membrane Versus Concentrated Growth Factor on Periodontal Ligament Model Defect

Authors

Ola Dewedar, Assistant Lecturer of Oral and Dental Biology, Faculty of Dental Medicine for Girls, Al-Azhar University, Cairo, EgyptFollow
Heba Adawy, Professor and head of Oral and Dental Biology, Faculty of Dental Medicine for Girls, Al-Azhar University, Cairo, EgyptFollow
Mai Attia, Professor of Oral Medicine, Periodontology, Oral Diagnosis and Radiology Faculty of Dental Medicine for Girls, Al-Azhar University, Faculty of Oral and Dental Medicine, Misr International University, Cairo, EgyptFollow
Mena Abdullah, Lecturer of Oral and Dental Biology, Faculty of Dental Medicine for Girls, Al-Azhar University, Cairo, EgyptFollow

Corresponding Author

Dewedar, Ola

Document Type

Original Study

Abstract

Purpose: This study was carried out to evaluate the effect of two different regenerative materials on periodontal Ligament Model Defect through histological examination of rabbit’s mandible. Material and Methods: Thirty-six (36) adult male New Zealand rabbits (weight 3 to 3.5 kg) were used and then divided randomly into 3 groups according to material received (n=12).Group I (GI) control group that did not receive any treatment, Group II (GII) that received polycarolactone nanofiber membrane (PCL), Group III (GIII) that received concentrated growth factor membrane (CGF), surgical procedures were done to create a bony defect of 5x5mm size in the right side on buccal mandibular bone, the rabbits were euthanized at day 7,30 and 45. Results: The histological evaluation showed that bone healing in bony defects of group III was faster than that of the other two groups. Group III showed the statistically significantly highest mean % increase in bone density than Group I and II. Conclusion: The regenerative therapy using (CGF) membrane showed an improvement in the treatment of periodontal ligament defects than those treated with (PCL) nanofiber membrane.

Keywords

Polycarolactone; concentrated growth factor; periodontal ligament defect

How to Cite This Article

Dewedar, Ola; Adawy, Heba; Attia, Mai; and Abdullah, Mena (2023) "Effect of Polycaprolactone Nanofiber Membrane Versus Concentrated Growth Factor on Periodontal Ligament Model Defect," Al-Azhar Journal of Dentistry: Vol. 10: Iss. 2, Article 25.
DOI: https://doi.org/10.58675/2974-4164.1512

Subject Area

Oral Medicine and Surgical Sciences Issue (Oral Medicine, Oral and Maxillofacial Surgery, Oral Pathology, Oral Biology)