•  
  •  
 

Corresponding Author

Romissaa A. Ismail

Document Type

Original Study

Abstract

Purpose: The current study was to evaluate the glycemic status, inducible nitric oxide synthase, and spontaneous neutrophil apoptosis in tested groups which were divided in to four groups; group (1) healthy group, group (2) periodontitis; group (3) diabetic group and group (4) diabetic with periodontitis. Subjects and Methods: There were 40 patients in all, and they were separated into four groups based on their state of health; group (1) healthy, group (2): periodontitis, group (3) type 2 diabetic patients and group (4) diabetic patients with periodontitis. Periodontal parameters, glycemic condition assessment using HbA1c, evaluation of polymorphous neutrophil apoptotic activity using flow cytometry, and measurement of inducible nitric oxide synthase were all carried out. Results: Glycated hemoglobin (HbA1C) level and spontaneous apoptosis percentage had a strong negative association (r = -0.813). The amount of spontaneous apoptosis and the duration of diabetes had a moderately negative connection (r = -0.622). HbA1C level and duration of diabetes were strongly positively correlated (r = 0.933). Age and spontaneous apoptosis showed a moderately negative link. Additionally, there was a moderately negative connection (r = -0.725) between iNos and spontaneous apoptosis percentage. Conclusion: Diminishing of apoptosis in diabetic with periodontitis group compared to healthy group. Additionally, high concentrations of iNos in diabetic with periodontitis group compared to healthy group. Also, disturbance of apoptosis related to inflammaging. The decline of apoptosis is associated with chronic disorders like diabetes and periodontal diseases. Additionally, high concentrations of iNos related to destructive mechanisms included more periodontal tissue destruction.

Keywords

PMN, Apoptosis, Type 2 diabetius, Periodontitis, iNos

Subject Area

Oral Medicine and Surgical Sciences Issue (Oral Medicine, Oral and Maxillofacial Surgery, Oral Pathology, Oral Biology)

Included in

Dentistry Commons

Share

COinS