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Corresponding Author

Asmaa A. Khater

Document Type

Original Study

Abstract

Purpose: This study was designed to evaluate the effect of Poly Amido Amine Dendrimer (PAMAM), Nano-hydroxyapatite (nHA), and Their Combination (PAMAM-nHA) on microhardness of demineralized enamel. Subjects and Methods: A total of thirty freshly extracted premolar human teeth were used in this study. Individual specimens were prepared and demineralized in a 37% phosphoric acid gel (H3 PO4) for 30 seconds before being divided into three groups based on the materials used for treatment of demineralized enamel. In the first group; PAMAM dendrimer was applied (A1), In the second group; Nanohydroxyapatite was applied (A2), in the third group; a combination of PAMAM dendrimer and Nanohydroxyapatite were applied (A3). The specimens were subdivided into three subgroups groups (T) according to assessment time. At baseline (T0), after 4 weeks (T1), and after 12 weeks (T2). Each treated group was placed in a separate container of artificial saliva which was replenished every 24 hours. All the specimens were subjected to microhardness assessment before demineralization (baseline), after demineralization, and 4 and 12 weeks after the application of the treatment materials using a Digital Display Vickers Microhardness Tester. Results: At 4 and 12 weeks the highest mean value was recorded for the PAMAM-nHA group followed by the nHA group while the PAMAM group recorded the lowest mean value, Group A3 was significantly the highest, while there was an insignificant difference between groups A1 & A2. Conclusion: All the treatment materials used in the study were effective in the microhardness recovery of enamel.

Keywords

Poly amido amine dendrimer, Nano-hydroxyapatite, demineralized enamel.

Subject Area

Restorative Dentistry Issue (Removable Prosthodontics, Fixed Prosthodontics, Endodontics, Dental Biomaterials, Operative Dentistry)

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