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Corresponding Author

Hagar Abdel Sabour

Document Type

Original Study

Abstract

Purpose: This work aimed to assess the effect of melatonin in comparison to bisphosphonates on induced osteoporotic alveolar bone of albino rats. Material and Methods: Twenty-eight female albino rats were used in this study divided into 4 equivalent groups (8 rats each) as follows: group I: normal control group, group II: glucocorticoid-induced osteoporotic group (GIO) (Dexamethasone 7mg/kg/week intramuscularly), group III: Alendronate group; rats received glucocorticoids in addition to alendronate (2mg/kg daily orally). Group IV: Melatonin received (7mg/kg/week IM) and Melatonin (5mg/kg/day subcutaneously). After 8 weeks, animals were sacrificed then blood was withdrawn for biochemical analysis, then the mandibular bone was taken for histological examination and for energy dispersive X-ray (EDX). Results: In GIO group: there was decrease in serum calcium, phosphorus, alkaline Phosphatase (ALP) and osteocalcin (OC) concentrations and also decrease in minerals content in tissue. Also by light microscope this group showed bone degeneration. Using melatonin and alendronate improved this degenerated change, but this improvement is better in melatonin than alendronate. Conclusions: Melatonin is more effective in restoration of bone architecture than alendronate in glucocorticoid-treated rats.

Keywords

Osteoporosis, Alendronate, Melatonin, Alveolar

Subject Area

Oral Medicine and Surgical Sciences Issue (Oral Medicine, Oral and Maxillofacial Surgery, Oral Pathology, Oral Biology)

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