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Document Type

Original Study

Abstract

The aim of the present study was to evaluate clinically and radiographically theeffectiveness of nano-crystalline hydroxyapatite (NcHA) versus hydroxyapatite (HA)crystals in the treatment of intrabony periodontal defects. Subjects and Methods:Twelve patients with bilateral defects, with probing depth (PD) ≥5 mm and clinicalattachment loss (CAL) ≥3 mm participated in the present study. Subjects were dividedrandomly into Group 1: 12 sites treated surgically with open flap debridement (OFD)and placement of NcHA (1) as a bone substitute. Group 2: 12 sites treated surgicallywith open flap debridement and placement of HA (2) as a bone substitute. The followingclinical parameters were recorded: PD, CAL, plaque index (PI), gingival index(GI), alveolar bone level percentage and bone density percentage. Results: At 6 monthsfollowing therapy, PD and CAL decreased by time, with a statistically significant differencein both groups .On comparison of the mean difference in PD and CAL between thetwo groups after Mann-Whitney U test was applied at baseline, 3 and 6 months, scoreswere found to be statistically non-significant (p>0.01). A significant reduction in PI andGI were recorded following therapy. As regard to radiographic bone measurements,in both groups, alveolar bone level percent decreased by time, with a non-significantdifference. The change occurring in the first interval was greater in both groups, with anon-significant difference. In both groups, bone density percent increased by time, witha significant difference. The change occurring in the second interval was greater in bothgroups, with a non-significant difference between changes occurring in both intervals.Conclusion: Both NcHA and conventional HA led to the improvement of clinical andradiographic parameters over the course of the study. The NcHA group did not showany significant improvement over the HA group.

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