Evaluation of Subantimicrobial Dose Doxycycline Effects on Dental Implant Osseointegration in Type II Diabetic Patients

Authors

Nora Abdel Rahman, Associate Lecturer of Oral Medicine, Periodontology, Oral diagnosis and Radiology Department. Faculty of Dental Medicine for Girls. Al-Azhar University.
Ossama Al Shal, Professor of Oral Medicine, Periodontology, Oral diagnosis and Radiology Department, Vice- Dean for Postgraduate Studies. Faculty of Dental Medicine for Girls. Al-Azhar University.
Olfat Shaker, Professor of Bio-Chemistry. Faculty of Medicine. Cairo University.
Mai Shafik, Associate Professor of Oral Medicine, Periodontology, Oral diagnosis and Radiology, Department. Faculty of Dental Medicine for Girls. Al-Azhar University.

Document Type

Original Study

Abstract

Objective : The present study was carried out to compare radiographic outcomes of dental implant in type II diabetic patients with or without adjunctive administration of subantimicrobial dose doxycycline. Subjects and Methods : This study included 20 patients with controlled type II diabetes mellitus of both genders, their age ranged from 40-48years.The study groups were designed in two groups, test group treated with dental implant with systemic administration of subantimicrobial dose doxycycline(SDD) for twice per day for 3 months and control group received dental implant alone. Results: Regarding radiographic marginal bone levels measurements; in both groups the mean marginal bone loss increased by time, with significant difference between both groups where the test group (SDD received group) showed the lower marginal bone loss values. In both groups, bone density measurements increased by time, with significant percentage change recorded for test group (SDD received group) 55.22% while control group recorded 17.40% from base line values. Conclusions: The use of sub-antimicrobial dose doxycycline with dental implants in type II diabetic patients was effective as an adjunctive host modulatory drug. Systemic administration of subantimicrobial dose doxycycline with dental implants in type II diabetic patients resulted in greater increase in bone density and less marginal bone loss thus subantimicrobial dose doxycycline can enhance the osseointegration of dental implants.

Keywords

Diabetes mellitus; Subantimicrobial dose doxycycline; dental implant; Cone beam computed tomography

How to Cite This Article

Abdel Rahman, Nora; Al Shal, Ossama; Shaker, Olfat; and Shafik, Mai (2018) "Evaluation of Subantimicrobial Dose Doxycycline Effects on Dental Implant Osseointegration in Type II Diabetic Patients," Al-Azhar Journal of Dentistry: Vol. 5: Iss. 3, Article 2.
DOI: https://doi.org/10.21608/adjg.2018.17152

Subject Area

Oral Medicine and Surgical Sciences Issue (Oral Medicine, Oral and Maxillofacial Surgery, Oral Pathology, Oral Biology)