Evaluation of GRP 78 Expression in Salivary Gland Tumors

Authors

amany taha, oral pathology department,faculty of dental medicine, alazhar university for girls, nasr city, cairoFollow
eman Abo Hager, professor of oral and dental pathologyFollow
adel shouman, professor of oral and dental pathologyFollow

Corresponding Author

taha, amany

Document Type

Original Study

Abstract

Purpose: The purpose of this work was to evaluate the expression of GRP78 as a prognostic indicator of aggressiveness in salivary gland tumors and to relate its expression with the biological behavior of the salivary gland tumors. Material and Method: 80 cases of salivary gland tissues were collected as paraffin embedded blocks: 30 benign cases (15 pleomorphic adenoma and 15 Warthin’s tumors) and 45 malignant cases (15 carcinoma ex pleomorphic adenomas, 15 mucoepidermoid carcinomas in addition to 15 adenoid cystic carcinoma). Additionally, 5 normal salivary gland tissues. Using GRP78 antibody, an immunohistochemical investigation was done for all specimens. Results: The mean area percent of immunoexpression was greatest in malignant variants of salivary gland tumors, followed by benign variants of salivary gland tumors and the least value recorded in normal salivary gland tissue. Conclusion: According to the current study, GRP78 is considered as a useful marker for diagnosis of malignancy of salivary gland.

Keywords

GRP78; Immunohistochemistry; salivary gland tumors

How to Cite This Article

taha, amany; Abo Hager, eman; and shouman, adel (2019) "Evaluation of GRP 78 Expression in Salivary Gland Tumors," Al-Azhar Journal of Dentistry: Vol. 6: Iss. 3, Article 4.
DOI: https://doi.org/10.21608/adjg.2019.7496.1076

Subject Area

Oral Medicine and Surgical Sciences Issue (Oral Medicine, Oral and Maxillofacial Surgery, Oral Pathology, Oral Biology)