Clinical and Radiographic Evaluation of Ten Congenital Insensitivity to Pain with Anhidrosis Patients

Authors

Heba Gamal El Din, Assistant Researcher of Oro-dental Genetics, Department of Oro-dental Genetics, Human genetics and genome research division, National Research Center, Cairo, EgyptFollow
Naglaa El kilani, Professor and Head of Oral medicine, Periodontology, Diagnosis and Radiology Department, Faculty of Dental medicine for Girls, Al Azhar university, Cairo, EgyptFollow
Mostafa Mostafa, Professor of Oro-dental Genetics, Department of Oro-dental Genetics, Human genetics and genome research division, National Research Center, Cairo, EgyptFollow
Inas Sayed, Researcher of Oro-dental Genetics, Department of Oro-dental Genetics, Human genetics and genome research division, National Research Center, Cairo, EgyptFollow
Samira Ismail, Professor of Clinical Genetics, Clinical Genetics Department, Human Genetics and Genome Research Division, National Research Center, Cairo, EgyptFollow
Eatemad Shoreibah, Professor of Oral medicine, Periodontology, Diagnosis and Radiology Department, Faculty of Dental medicine for Girls, Al Azhar university, Cairo, EgyptFollow

Corresponding Author

Gamal El Din, Heba

Document Type

Original Study

Abstract

Purpose: This study was designed to introduce a standardized protocol for examination of congenital insensitivity to pain with anhidrosis patients. And also report the oro-dental manifestations in these patients. Materials and methods: In the current study, Oro-facial clinical and sensory examinations, as well as radiographic examination for ten CIPA patients were performed. Results: The Oro-dental findings were mainly missing teeth and soft tissue injuries. Radiographic examination revealed multiple congenitally missing teeth. Conclusion: A standardized protocol with Oro-facial clinical and sensory examinations, pulp sensitivity tests and radiographic examination should be considered as a primary diagnostic approach in patients with suspected Congenital insensitivity to pain with anhidrosis, instead of the more established but expensive molecular analysis and the invasive Sural nerve biopsy.

Keywords

anhidrosis; Self-mutilation; oro-facial injuries; premature tooth loss

How to Cite This Article

Gamal El Din, Heba; El kilani, Naglaa; Mostafa, Mostafa; Sayed, Inas; Ismail, Samira; and Shoreibah, Eatemad (2020) "Clinical and Radiographic Evaluation of Ten Congenital Insensitivity to Pain with Anhidrosis Patients," Al-Azhar Journal of Dentistry: Vol. 7: Iss. 4, Article 1.
DOI: https://doi.org/10.21608/adjg.2020.13139.1150

Subject Area

Oral Medicine and Surgical Sciences Issue (Oral Medicine, Oral and Maxillofacial Surgery, Oral Pathology, Oral Biology)