Evaluation of Serum Interleukin-10 and Matrix Metalloproteinase-9 Levels as Predictors of Glycemic Alteration in Type 2 Diabetes Mellitus in Patients with Periodontitis

Authors

Ayman Elgawish, Assistant lecturer of Oral Medicine, Periodontology, Oral Diagnosis and Dental Radiology, British University in Egypt, Cairo, EgyptFollow
Hala Hazzaa, Professor of Oral Medicine, Periodontology, Oral Diagnosis and Radiology, Faculty of Dental Medicine for Girls, Al-Azhar University, Cairo, Egypt
Eatemad Shoreibah, Professor of Oral Medicine, Periodontology, Oral Diagnosis and Radiology, Faculty of Dental Medicine for Girls, Al-Azhar University, Cairo, Egypt

Corresponding Author

Elgawish, Ayman

Document Type

Original Study

Abstract

Purpose: The present study was conducted to evaluate serum interleukin-10 and MMP-9 levels as predictors of glycemic alteration in type 2 Diabetic patients with periodontitis. Subjects and methods: This study was conducted on thirty (30) patients that were divided into two groups: Group 1 fifteen (15) patients with type 2 diabetes and periodontitis; Group 2 fifteen (15) patients with type 2 diabetes and c periodontitis receiving adjunctive treatment Omega-3 and aspirin. Elisa kit was used to evaluate the concentration of serum Mmp-9 and IL-10. Results: There was a statistically significant difference between (Group 1) and (Group 2) in the serum level of Mmp-9 (P-value 0.028) (P-value 0.010) after 3m and 6m as well as the serum level of IL-10(P-value 0.020) (P-value 0.029). Conclusion: Serum IL-10 can be used as predictor of glycemic alteration in type 2 Diabetes Mellitus.Omega-3 can be used as adjunctive treatment in periodontal disease.

Keywords

Periodontitis; Type 2 Diabetes; MMP-9; IL-10; Omega-3 and aspirin

How to Cite This Article

Elgawish, Ayman; Hazzaa, Hala; and Shoreibah, Eatemad (2020) "Evaluation of Serum Interleukin-10 and Matrix Metalloproteinase-9 Levels as Predictors of Glycemic Alteration in Type 2 Diabetes Mellitus in Patients with Periodontitis," Al-Azhar Journal of Dentistry: Vol. 7: Iss. 4, Article 12.
DOI: https://doi.org/10.21608/adjg.2020.14148.1176

Subject Area

Oral Medicine and Surgical Sciences Issue (Oral Medicine, Oral and Maxillofacial Surgery, Oral Pathology, Oral Biology)