Effect of Mesenchymal Stem Cell Injection on Healing Outcome in Secondary Cleft Lip Correction

Authors

Somaya Zakeer, Demonstrator at Oral and Maxillofacial Surgery Department, Faculty of Oral and Dental Medicine for Girls, Al-Azhar University, Cairo, Egypt.Follow
Hatem Al.Ahmady, Professors of Oral and Maxillofacial Surgery, Faculty of Oral and Dental medicine for Girls, Al-Azhar University, Cairo, Egypt.Follow
Nahed Adly, Lecturer of Oral and Maxillofacial Surgery, Faculty of Oral and Dental medicine for Girls, Al-Azhar University, Cairo, Egypt.Follow
Ahmed Zidan, Lecturer of Diagnostic Radiology, Faculty of Medicine for Boys, Al-Azhar University, Cairo, Egypt.Follow
ahmed Abd Alzeem, Assistant researcher at Orodental Genetics Department, Human Genetic Division, National Research Center, Cairo, Egypt.Follow

Corresponding Author

Zakeer, Somaya

Document Type

Original Study

Abstract

Purpose: This study aimed to evaluate the effect of intraoperative mesenchymal stem cell injection on healing outcome in secondary cleft lip correction. Patients and Methods: A total of ten patients with secondary cleft lip deformities who needed secondary cleft lip repair were included in this study. The patients were divided equally into two groups: group I (study group) were subjected to secondary cleft lip repair with immediate intraoperative bone marrow mesenchymal stem cells injection (BM-MSCs), group Ⅱ (control group) who didn’t receive any type of injection neither during surgery nor after. The healing out come and scar progression were recorded through photographs and Ultrasonography (US). Results: Group I showed higher rate in primary healing outcome than that of group Ⅱ. The Ultrasound revealed statistically significant difference in scar progression in both groups. Group I showed statistically significant difference in scar measurements across time than group Ⅱ in p < 0.01. Conclusion: Bone marrow mesenchymal stem cell injection in cleft lip correction has a good effect on primary healing outcome and scar progression.

Keywords

Bone Marrow Mesenchymal Stem Cell; Ultrasonography

How to Cite This Article

Zakeer, Somaya; Al.Ahmady, Hatem; Adly, Nahed; Zidan, Ahmed; and Abd Alzeem, ahmed (2020) "Effect of Mesenchymal Stem Cell Injection on Healing Outcome in Secondary Cleft Lip Correction," Al-Azhar Journal of Dentistry: Vol. 7: Iss. 4, Article 14.
DOI: https://doi.org/10.21608/adjg.2020.23227.1229

Subject Area

Oral Medicine and Surgical Sciences Issue (Oral Medicine, Oral and Maxillofacial Surgery, Oral Pathology, Oral Biology)