Evaluation of 3D Printed Computer Assisted Patient’s Specific Scaffold Seeded by Autologous Bone Marrow Mononuclear Cells in Mandibular Reconstruction

Authors

Wafaa Mohammed, Demonstrator of Oral and Maxillofacial Surgery, Faculty of Dental Medicine for Girls, Al-Azhar University, Cairo, Egypt.Follow
Suzan Hassan, Professor of Oral and Maxillofacial Surgery, Faculty of Dental Medicine for Girls, Al-Azhar University, Cairo, Egypt.Follow
Hatem ALahmady, Professor of Oral and Maxillofacial Surgery and Head of Department, Faculty of Dental Medicine for Girls, Al-Azhar University, Cairo, Egypt.Follow
Wael Shawkat, Head of Oral and Maxillofacial Surgery Department, Health insurance hospital, Cairo, Egypt.Follow
Ahmad Abd Elazeem, Assistant researcher of regenerative medicine and genetics, Oro-dental Genetics Department, Human Genetics Division, National Research Center, Cairo, Egypt.Follow
Ibrahim ELsharabasy, Consultant of Oral and Craniomaxillofacial Surgery.Follow
Ismail Nazif, Electrical and Medical 3D Printing Engineer.Follow

Corresponding Author

Mohammed, Wafaa

Document Type

Original Study

Abstract

Purpose: This study was carried out to evaluate both clinically and radiographicly the use of 3D printed computer assisted patient’s specific scaffold seeded with ABMMCs in mandibular reconstruction. Materials and methods: The present study was conducted on eight patients who needed mandibular reconstruction. All patients in this study were subjected to mandibular reconstruction using 3D printed computer assisted patients specific scaffold using PLLA scaffold seeded with ABMMCs combined with osteoplastic materials of biological origin as Osteomatrix (LLC Konectbiopharm, Russia) which composed of natural collagen and hydroxyapatite with affinity-bound sulfated glycosaminoglycan (SGAG). All patients underwent preoperative cranial-maxillofacial CT scans, immediate postoperative and after six months for assessment of bone density and volume changes. Results: The reduction in bone density (17.4%) and bone volume (14.5%) from immediate to six months was statistically significant. There was an increase in bone density in the area near the autogenous bone of the patient than the area far from the autogenous bone of the patient. Conclusion: Using 3D printed computer assisted patient’s specific scaffold seeded with ABMMCs combined with Osteoplastic materials of biological origin in mandibular reconstruction is useful in small defects.

Keywords

Mandibular reconstruction; Poly (L-lactide) lactic acid; 3D printed

How to Cite This Article

Mohammed, Wafaa; Hassan, Suzan; ALahmady, Hatem; Shawkat, Wael; Abd Elazeem, Ahmad; ELsharabasy, Ibrahim; and Nazif, Ismail (2021) "Evaluation of 3D Printed Computer Assisted Patient’s Specific Scaffold Seeded by Autologous Bone Marrow Mononuclear Cells in Mandibular Reconstruction," Al-Azhar Journal of Dentistry: Vol. 8: Iss. 1, Article 14.
DOI: https://doi.org/10.21608/adjg.2021.23389.1237

Subject Area

Oral Medicine and Surgical Sciences Issue (Oral Medicine, Oral and Maxillofacial Surgery, Oral Pathology, Oral Biology)