Evaluation of the Addition of Injectable Platelet Rich Fibrin to Xenograft in Management of Periodontal Intraosseous Defects. “Randomized Controlled Trial”

Authors

Ahmed Elbarbary, Assistant professor Oral Medicine, Diagnosis and Periodontology Department, Faculty of Dentistry, Cairo University, Cairo, Egypt.Follow
Ahmed Reda, Assistant professor Oral Medicine, Diagnosis and Periodontology Department, Faculty of Dentistry, Cairo University, Cairo, Egypt.
Ahmed Abd ELaziz, Assistant professor Oral Medicine and Periodontology Department, Faculty of Dentistry, Ain Shams University, Cairo, Egypt.

Corresponding Author

Elbarbary, Ahmed

Document Type

Original Study

Abstract

Purpose: Platelet rich fibrin (PRF) has been widely and successfully used in periodontal regeneration. Injectable PRF (i PRF) is a liquid form of PRF containing more leucocyte and growth factors. I-PRF was used with great success in management of gingival recession and implant therapy. So the aim of the study was to evaluate the benefit of adding i-PRF to xenograft in management of periodontal intraosseous defects. Subjects and Methods: Twenty four patients (age range 36 - 59 years), with stage III periodontitis with at least one intrabony defect, probing pocket depth > 5 mm and radiographic evidence of vertical bone loss, were enrolled in the present study. The patients were equally divided into two groups, the test group (i-PRF and xenograft) and the control group (xenograft only). Probing depth (PD), clinical attachment level (CAL.), bone defect depth and bone density were recorded at baseline and after 6 months. Results: The results showed a statistical significant reduction in PD, gain in CAL, bone fill and change in bone density from preoperative to 6 months in each group separately. There was a statistical significant difference between test and control groups with mean and standard deviation (SD) of PD reduction (4.2±0.4; 3.3±0.7) and CAL gain (3.8±0.4 ; 2.9±0.8) respectively in favor of the test group. Regarding bone fill, there was no statistical significant difference between both groups with mean and SD (2.6±0.7; 2±0.8) respectively. As for the increase in bone density, there was a statistical significant difference between both groups with mean and SD (17.5±4.9 ;10.9±6.8) respectively. Conclusion: We can conclude that adding i-PRF to bone grafting material might have a beneficial impact in treatment of periodontal intraosseous defects.

Keywords

injectable; Platelet rich fibrin; Intraosseous defects; Xenograft; Regeneration

How to Cite This Article

Elbarbary, Ahmed; Reda, Ahmed; and Abd ELaziz, Ahmed (2022) "Evaluation of the Addition of Injectable Platelet Rich Fibrin to Xenograft in Management of Periodontal Intraosseous Defects. “Randomized Controlled Trial”," Al-Azhar Journal of Dentistry: Vol. 9: Iss. 2, Article 15.
DOI: https://doi.org/10.21608/adjg.2022.111166.1461

Subject Area

Oral Medicine and Surgical Sciences Issue (Oral Medicine, Oral and Maxillofacial Surgery, Oral Pathology, Oral Biology)